Titre
Airway inflammation in asthma : from concept to the clinic
Auteur
Rensen, Elizabeth L.J. van
Langue
anglais
ISBN
9789090203751
Éditeur
Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University 2006 9789090203751
Prix
€ 11,70
Détails
160pp, Paperback / softback 160pp. in goede staat
Plus d'informations
Keywords: Asthma
Airway inflammation
Eosinophils
CD8+ cells
Anti-IgE
Sputum
Bronchial biopsies
Airway hyperresponsiveness
PEF-variability
Allergen challengeThree aspects of airway inflammation in asthma were investigated in this thesis: proof of concept, monitoring and management.
In chapter 2 is shown that IL-5 is mainly effective in the circulation.
In chapter 3 is shown that steroids improve airway hyperresponsiveness, sputum eosinophils, and NO. The changes were not related. This suggests that these markers may provide different information when monitoring anti-inflammatory treatment in asthma.
In chapter 4 is shown that alpha-2-macroglobulin is an appropriate marker for measuring microvascular leakage in sputum. This "dual induction" model may used when testing the antiexudative effect of drugs.
Chapter 5 demonstrated that the annual decline in FEV1 is related with CD8+ cells. This suggests that inflammatory phenotypes in asthma may have prognostic relevance.
In chapter 6 is shown that PEF-variability provides information about asthma severity. Therefore, the current guidelines for the treatment of asthma can be improved by including PEF-variability.
In chapter 7 is shown that anti-IgE improves PEF, diminishes allergen responses and is paralleled by a reduction in eosinophils in biopsies and sputum and a decline in IgE+ cells. This suggests that the clinical benefits of anti-IgE in asthma may be explained by a decrease in eosinophilic inflammation and IgE bearing cells.
Airway inflammation
Eosinophils
CD8+ cells
Anti-IgE
Sputum
Bronchial biopsies
Airway hyperresponsiveness
PEF-variability
Allergen challengeThree aspects of airway inflammation in asthma were investigated in this thesis: proof of concept, monitoring and management.
In chapter 2 is shown that IL-5 is mainly effective in the circulation.
In chapter 3 is shown that steroids improve airway hyperresponsiveness, sputum eosinophils, and NO. The changes were not related. This suggests that these markers may provide different information when monitoring anti-inflammatory treatment in asthma.
In chapter 4 is shown that alpha-2-macroglobulin is an appropriate marker for measuring microvascular leakage in sputum. This "dual induction" model may used when testing the antiexudative effect of drugs.
Chapter 5 demonstrated that the annual decline in FEV1 is related with CD8+ cells. This suggests that inflammatory phenotypes in asthma may have prognostic relevance.
In chapter 6 is shown that PEF-variability provides information about asthma severity. Therefore, the current guidelines for the treatment of asthma can be improved by including PEF-variability.
In chapter 7 is shown that anti-IgE improves PEF, diminishes allergen responses and is paralleled by a reduction in eosinophils in biopsies and sputum and a decline in IgE+ cells. This suggests that the clinical benefits of anti-IgE in asthma may be explained by a decrease in eosinophilic inflammation and IgE bearing cells.
Images
hasselman
Breda 
Levering binnen Nederland ( 3,90 euro verzendkosten )
Levering binnen de EU is mogelijk bij bestellingen vanaf 15 euro plus bijkomende internationale verzendkosten.
Afhalen is niet mogelijk.
- Tous les livres sont en état complet et normal, sauf indication contraire. De petites imperfections comme une page collée ou un nom sur la feuille ne sont pas toujours mentionnés
- Vous gérez directement cette commande avec hasselman
- Après votre commande vous et hasselman recevrez une confirmation par e-mail. Dans l'e-mail que vous pouvez trouver, vous pouvez trouver le nom et l'adresse de hasselman
- L'acheteur paie les frais de livraison, sauf accord contraire
- hasselman peut demander un prépaiement
- Boekwinkeltjes.nl essaie de rapprocher les acheteurs et les vendeurs. Boekwinkeltjes.nl n'est jamais impliqué dans un accord entre l'acheteur et le vendeur. Si vous avez un différend avec un ou plusieurs utilisateurs, vous devez le réparer vous-même. Vous indemnisez Boekwinkeltjes.nl de toute réclamation.